Author

Ruhong Tu

Columbia University Irving Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

Biyun ZhengiD· 5 shared Feijing WuiD· 5 shared Hiroki KobayashiiD· 5 shared Jin QianiD· 5 shared Leah B. ZamechekiD· 5 shared TIMOTHY Cragin WANGiD· 5 shared Yosuke OchiaiiD· 5 shared Hualong ZhengiD· 4 shared

Activity by Year

2024-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

Biyun ZhengORCID

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5 papers

Recent·Most cited

A microbiota-driven neuroepithelial feed-forward circuit drives gastroesophageal junction tumorigenesis

Yi Zeng, Zaisheng Ye, Feijing Wu, Puran Zhang, Hiroki Kobayashi, Junya Arai, Xiaofei Zhi, Martin Borgmann, Jin Qian, Shuang Li, Biyun Zheng, Hualong Zheng, Ruhong Tu, Juli Lin, Masahiro Hata, , TIMOTHY Cragin WANG

This paper identifies a microbiota-driven neuroepithelial circuit that promotes GEJ tumorigenesis through bile acid remodeling and bacterial metabolites.

bioRxiv · Oct 15, 2026 · PreprintCancer Biology

Endocrine Neural Interactions Regulate Antral CCK2R+ Stem Cells in Gastric Inflammation and Preneoplasia

Biyun Zheng, Hualong Zheng, Ruhong Tu, Fenglin Chen, Jiaoqian Lu, Hiroki Kobayashi, Puran Zhang, Yi Zeng, Guodong Lian, Feijing Wu, Xiaozhong Wang, Xiaofei Zhi, Kexuan Huang, Jin Qian, Quin T. Waterbury, , Timothy Cragin Wang

The paper shows that gastrin loss activates a vagal reflex that promotes CCK2R+ stem cell expansion and preneoplasia in gastric inflammation.

bioRxiv · Aug 31, 2026 · PreprintCell Biology

Sensory neurons encode long-term inflammatory memory that promotes gastric regeneration and tumorigenesis

Yi Zeng, Puran Zhang, Feijing Wu, Ruhong Tu, Xiaofei Zhi, Hiroki Kobayashi, Jin Qian, Yosuke Ochiai, Biyun Zheng, Hualong Zheng, Shuang Li, Jinghan Lin, Masahiro Hata, Quin T. Waterbury, Junya Arai, , Timothy Cragin Wang

This paper shows that sensory neurons form long-term inflammatory memory, enhancing gastric regeneration and tumor susceptibility after injury.

bioRxiv · Jun 19, 2026 · PreprintCancer Biology

Tff2 marks gastric corpus progenitors that give rise to pyloric metaplasia/SPEM following injury

Ruhong Tu, Hua-Long Zheng, Biyun Zheng, Qing Zhong, Jin Qian, Qian Yu, Feijing Wu, Toshiro Shiokawa, Yosuke Ochiai, Hiroki Kobayashi, Quin T. Waterbury, Leah B. Zamechek, Youxin Gao, Satoru Takahashi, Seiya Mizuno, , Timothy Cragin Wang

This study identifies Tff2+ progenitors in the gastric corpus as the primary source of SPEM and gastric cancer following injury, showing they can bypass metaplasia and progress directly to dysplasia.

Gut · Apr 14, 2026Peer-reviewedCell Biology

A CXCR4 partial agonist improves immunotherapy by targeting polymorphonuclear myeloid-derived suppressor cells and cancer-driven granulopoiesis

Jin Qian, Chenkai Ma, Quin T. Waterbury, Xiaofei Zhi, Christine S. Moon, Ruhong Tu, Hiroki Kobayashi, Feijing Wu, Biyun Zheng, Yi Zeng, Hualong Zheng, Yosuke Ochiai, Ruth Aroon White, David W Harle, Jonathan S. LaBella, , Timothy Cragin Wang

This paper shows that a CXCR4 partial agonist enhances immunotherapy in gastric cancer by targeting PMN-MDSCs and granulopoiesis.

Cancer Cell · Oct 11, 2024Peer-reviewedCancer Biology