Yongwei Zhang

This study shows that reducing MSH3 in Huntington's disease mouse models prevents somatic CAG repeat expansion but does not accelerate disease onset, suggesting somatic expansion may not be required for pathogenesis.

This study compares SARS-CoV-2 viral populations in COVID-19 patients to show narrow transmission bottlenecks and stochastic dynamics in intra-host and inter-host evolution.

This study uses whole genome sequencing of cell-free DNA to identify tissue-of-origin patterns, achieving high specificity and sensitivity in cancer patients.

The paper defines resected DSB structures in mouse spermatocytes, identifies ATM as a key regulator of resection, and shows PRDM9-dependent chromatin remodeling at recombination sites.

The DNBelab C4 portable, negative-pressure microfluidic device performs high-throughput single-cell transcriptome profiling, resolving species-specific cells and tissue heterogeneity in murine lung and cerebral cortex comparably to existing platforms.

This study shows that a functional MutSγ complex is required for all crossovers in mammalian meiosis, even though class II crossovers were thought to be MutSγ-independent.

The paper evaluates index mis-assignment rates on DNB-based sequencing platforms and finds they are exceptionally low, suggesting reliable multiplex sequencing.