Roman Vetter

The paper quantifies the rearrangement of the embryonic bronchial tree into its fractal architecture and identifies biophysical principles governing its formation, showing these principles persist in adulthood and disease.

The paper develops a mathematical framework to model directed cell migration as a mechanism for spatial pattern formation in development.

OptiCell3D infers mechanical cell properties from 3D microscopy data, showing that apical to lateral surface tension ratio predicts cell aspect ratio in epithelial tissues.

The paper challenges the traditional view that morphogen concentration fluctuations determine transition zone width, showing instead that cellular readout noise is the key factor.

The paper proposes a mechanism by which morphogen gradients encode both position and time in growing tissues through dynamic signal patterns.

The paper introduces SimuCell3D, a 3D simulation tool for tissue mechanics that enables detailed study of cell organization and biomechanical parameters in various tissue geometries.

The paper shows geometric effects concentrate WNT9b at branch junctions during kidney development, positioning renal vesicles.

The paper shows that 2D diffusion effects improve the precision of gradient-based tissue patterning compared to 1D models.

The paper analyzes how cell size and gradient parameters affect morphogen gradient precision, showing that smaller cell areas enhance patterning accuracy in developing tissues.

This study compares the positional error of morphogen gradients under linear and non-linear decay using simulations, finding minimal reduction in error for physiological noise levels and larger error for non-linear decay far from the source in tissues with flux barriers.

The paper develops a formalism to estimate morphogen gradient precision from molecular noise data, showing gradients can achieve high precision sufficient for developmental patterning.

This study uses a computational model to show that neural tube closure in mammals requires mesoderm and non-neural ectoderm expansion along with zippering, not just intrinsic curvature.

The paper shows fluid flow-induced shear stress drives biased epithelial tube elongation in lung and kidney development, independent of other factors.