Dagmar Iber

The paper quantifies the rearrangement of the embryonic bronchial tree into its fractal architecture and identifies biophysical principles governing its formation, showing these principles persist in adulthood and disease.

The paper develops a mathematical framework to model directed cell migration as a mechanism for spatial pattern formation in development.

OptiCell3D infers mechanical cell properties from 3D microscopy data, showing that apical to lateral surface tension ratio predicts cell aspect ratio in epithelial tissues.

The paper challenges the traditional view that morphogen concentration fluctuations determine transition zone width, showing instead that cellular readout noise is the key factor.

The paper proposes a mechanism by which morphogen gradients encode both position and time in growing tissues through dynamic signal patterns.

The paper introduces SimuCell3D, a 3D simulation tool for tissue mechanics that enables detailed study of cell organization and biomechanical parameters in various tissue geometries.

The paper shows geometric effects concentrate WNT9b at branch junctions during kidney development, positioning renal vesicles.

The paper shows that 2D diffusion effects improve the precision of gradient-based tissue patterning compared to 1D models.

The paper analyzes how cell size and gradient parameters affect morphogen gradient precision, showing that smaller cell areas enhance patterning accuracy in developing tissues.

This study compares the positional error of morphogen gradients under linear and non-linear decay using simulations, finding minimal reduction in error for physiological noise levels and larger error for non-linear decay far from the source in tissues with flux barriers.

The paper investigates the role of the protooncogene Ski in regulating the neuron-glia switch during mammalian cerebral cortex development and identifies its interaction with the BMP signaling pathway.

The paper maps transcriptional dynamics in murine cortical development, identifying lineage shifts and gene regulatory networks in neural stem cells, basal progenitors, and newborn neurons.

This study shows FGF8 promotes chemokinesis in mouse nephron progenitor cells, facilitating their condensation around ureteric buds.

The paper identifies tissue-enriched ligands involved in epithelial-endothelial crosstalk during pancreas development using scRNA-seq and computational interactomics.

FollicleFinder automates 3D segmentation of human ovarian follicles and measures morphological properties like diameter, surface area, and volume.

The paper develops a formalism to estimate morphogen gradient precision from molecular noise data, showing gradients can achieve high precision sufficient for developmental patterning.

The paper develops a 3D atlas of the embryonic pancreas to analyze cell interactions and spatial organization in mouse embryos.

This study uses a computational model to show that neural tube closure in mammals requires mesoderm and non-neural ectoderm expansion along with zippering, not just intrinsic curvature.

The paper shows fluid flow-induced shear stress drives biased epithelial tube elongation in lung and kidney development, independent of other factors.

This study uses light-sheet microscopy to analyze embryonic Chd8+/- mouse brains and finds decreased lateral ventricular sphericity and increased intraocular distance.

The paper identifies a Shh/Gli-driven three-node timer motif that controls the sequential generation of motor neurons and serotonergic neurons in the brainstem.

This study uses cell-based simulations to show that Notch signalling in developing pancreatic tissue is influenced by geometric effects and ligand expression changes, leading to distinct cell differentiation patterns.

This study identifies Notch2 and Id4 as regulators of neural stem cell quiescence in the adult hippocampus, showing their role in maintaining dormancy and affecting neurogenesis.

The paper proposes that positional information during vertebrate segmentation is encoded in the dynamic differences between neighboring oscillators, supported by quantitative analysis of in vivo and ex vivo mouse data.

The paper develops a mechanistic model of the her1 oscillator in zebrafish to explain how time-delayed juxtacrine coupling and autorepression drive collective oscillatory dynamics and travelling waves in somitogenesis.