Katie McDole

Choreographed morphogenetic events underlie early foregut development in the mouse embryo

The paper investigates the morphogenetic events during early foregut development in the mouse embryo, revealing a coordinated geometric process involving apoptosis and BMP2 signaling.

Dissecting human fetal cardiac repair using cardioids

This study uses a human cardioid injury platform to investigate immune-ECM-cardiomyocyte interactions in fetal cardiac repair, identifying key signaling pathways and cellular behaviors involved in regeneration.

A quantitative coordinate system for developmental dynamics

This paper introduces STERN, a framework that quantitatively compares developmental trajectories across embryos by learning spatiotemporal representations from 4D imaging data.

Primordial germ cells experience increasing physical confinement and DNA damage during migration in the mouse embryo

This study shows that migrating mouse primordial germ cells face increasing physical confinement and DNA damage during their journey to the gonads.

Competing regulatory modules control the transition between mammalian gastrulation modes

The paper identifies two regulatory modules that control the sequential transition between early and late gastrulation modes in mouse gastruloids.

Epigenetic priming of embryonic lineages in the mammalian epiblast

The paper identifies epigenetic priming of lineage-specific fates in the mammalian epiblast, revealing early specification of endothelial and mesodermal lineages.

Automated Reconstruction of Whole-Embryo Cell Lineages by Learning from Sparse Annotations

This paper introduces a method for automated lineage reconstruction in developing embryos using sparse annotations, achieving 75.8% accuracy on mouse embryos compared to 31.8% previously.

Hingepoint emergence in mammalian spinal neurulation

This study uses a computational model to show that neural tube closure in mammals requires mesoderm and non-neural ectoderm expansion along with zippering, not just intrinsic curvature.