Shawn C. Musial

Common viral infections seed regionally distinct resident memory T cells in the human CNS

The paper identifies regionally distinct CD8+ resident memory T cells in the human CNS shaped by viral infections using single-cell RNA sequencing and T cell receptor analysis.

Circulating and brain-resident memory CD8+ T cells seed distinct bystander TRM-like populations in glioblastoma

This study identifies that circulating and brain-resident memory CD8+ T cells contribute to distinct bystander TRM-like populations in glioblastoma, with brain TRM being a major source in GBM.

Hierarchal single-cell lineage tracing reveals differential fate commitment of CD8 T-cell clones in response to acute infection.

This study uses single-cell lineage tracing to show that CD8 T-cell clones exhibit differential fate commitment during acute infection, with some clones adopting memory or effector biases over time.

Alarm functions of PD-1+ brain resident memory T cells

This study shows brain-resident memory T cells (TRM) can rapidly remodel the CNS immune landscape through activation of multiple immune cells, and PD-1 inhibits granzyme B but not alarm responses.

CD39 is expressed on functional effector and tissue resident memory CD8+ T cells

This study identifies CD39 expression on functional effector and tissue-resident memory CD8+ T cells, showing its role in memory differentiation and function, distinct from its role in T cell exhaustion.