Tim Vanmierlo

This study identifies specific myelin disruption in cortical grey matter of Alzheimer's disease, linked to tau pathology and impaired oligodendrocyte differentiation.

This study shows that ST3GAL3 loss-of-function disrupts synaptic integrity and E/I cortical dynamics in human iPSC-derived neurons.

The paper identifies D6PV, a peptide that enhances remyelination by boosting oxidative phosphorylation in oligodendrocytes without affecting immune responses.

This study evaluates the effects of PDE4D inhibition on spinal cord injury outcomes, showing improved functional and histopathological results compared to PDE4B inhibition.

This study shows that carnosine synthase deficiency worsens neuroinflammation in MS models but not demyelination, suggesting a role in neuroinflammation regulation.

The paper investigates DNA methylation and transcriptomic changes in chronic demyelinated MS lesions, showing hypermethylation of myelination-related genes and demonstrating reversible effects through epigenetic editing.

This study shows that administering recombinant mouse mast cell protease 6 improves functional recovery after spinal cord injury by reducing demyelination and astrogliosis.