Daniël van den Hove

This study identifies specific myelin disruption in cortical grey matter of Alzheimer's disease, linked to tau pathology and impaired oligodendrocyte differentiation.

This study shows that ST3GAL3 loss-of-function disrupts synaptic integrity and E/I cortical dynamics in human iPSC-derived neurons.

This study identifies two epigenomic subtypes of late-onset Alzheimer's disease with distinct microglial and neuronal methylation signatures, linking them to different inflammatory and functional pathways.

CEAM is a tool for analyzing DNA methylation data to identify cell type-specific patterns, validated on neurodegenerative disease datasets.

This study shows repetitive neonatal pain increases spinal cord DNA methylation of the μ-opioid receptor gene Mor-1 in rats.

The paper develops a multivariate methylation risk score using blood DNA methylation data to predict dementia risk and cognitive impairment in Alzheimer's and Parkinson's disease cohorts.

This study shows Src kinase is upregulated and phosphorylated in Alzheimer's disease, interacts with Tau, and may be a therapeutic target.

The paper investigates DNA methylation and transcriptomic changes in chronic demyelinated MS lesions, showing hypermethylation of myelination-related genes and demonstrating reversible effects through epigenetic editing.

This study performs a meta-analysis of DNA methylation data from Alzheimer's disease patients to identify differentially methylated loci across brain regions and cortex.

This study compares intermittent and continuous deep brain stimulation of the nucleus basalis of Meynert in a transgenic rat model of Alzheimer’s disease, finding that intermittent stimulation improves spatial memory performance.