Klaus‐Peter Lesch

This study shows that ST3GAL3 loss-of-function disrupts synaptic integrity and E/I cortical dynamics in human iPSC-derived neurons.

This study compares thalamic nucleus volumes across multiple psychiatric and neurological disorders using MRI, finding significant volume reductions in specific regions associated with different conditions.

This study examines how serotonin transporter deficiency affects parvalbumin- and neuropeptide Y-producing interneurons in the basolateral amygdala of mice, showing reduced NPY neuron numbers and altered receptor expression.

This study identifies cell-type-specific epigenetic changes in TNXB in Alzheimer's disease using bulk and single-cell analyses of the dorsal raphe nucleus.

This study identifies four genetic factors underlying 11 psychiatric disorders and finds limited evidence for a single dimension of genetic risk across them.

This study investigates the role of CDH13 in regulating GABAergic inhibition in human-derived neuronal networks and shows its impact on E/I balance.

This study analyzes structural brain asymmetries in ADHD using 39 datasets, finding small effects that do not meet study-wide significance thresholds.

This study uses machine learning to show that structural brain anomalies in ADHD are similar in children and adults, supporting continuity of the disorder's pathophysiology.

The paper identifies genetic loci associated with brainstem volumes and finds genetic overlaps with psychiatric and neurological disorders.

This study identifies nine new genetic loci associated with ADHD and shows shared genetic architecture between childhood and adult ADHD.

The paper estimates brain age gaps using MRI and machine learning in individuals with and without brain disorders, finding heritability and genetic overlap with common disorders.

This study identifies Fgf3 as essential for generating monoaminergic cerebrospinal fluid-contacting cells in zebrafish hypothalamus, showing its role through regulation of etv5b and a compensatory mechanism.

Genome-wide association meta-analysis of 20,183 ADHD cases and 35,191 controls finds 12 significant loci; signal concentrates in conserved regions, constrained genes, and CNS regulatory elements.