Author

Michael G. Sacher

Concordia UniversityORCID 0000-0003-2926-5064Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Miroslav P. MileviD· 3 shared Hashem A AlmousaiD· 2 shared Paria Asadi· 2 shared Aashiq Hussain KachrooiD· 1 shared Arian MansuriD· 1 shared Brittany M. Greco· 1 shared Cadence Pearce· 1 shared Chelsea Abboud· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersGenetics

Miroslav P. MilevORCID

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3 papers

Recent·Most cited

GeneticsCellsPeer-reviewedAug 30, 2024

A humanized yeast model for studying TRAPP complex mutations; proof-of-concept using variants from an individual with a TRAPPC1-associated neurodevelopmental syndrome

Erta Zykaj, Chelsea Abboud, Paria Asadi…·Michael G. Sacher

This study develops a humanized yeast model to study TRAPP complex mutations, showing that human TRAPPC1 variants cause secretion and autophagy defects in yeast, mirroring human fibroblast defects.

3 citations

yeastexperimental assay

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Cell BiologyBiochemical and Biophysical Research CommunicationsPeer-reviewedMay 3, 2024

Lipidomic analysis of human TANGO2-deficient cells suggests a lipid imbalance as a cause of TANGO2 deficiency disease

Mahsa Mehranfar, Paria Asadi, Rozmehr Shokohi…·Michael G. Sacher

This study identifies lipid imbalances in TANGO2-deficient human cells and shows vitamin B5 supplementation rescues these imbalances, suggesting a role for TANGO2 in lipid metabolism.

15 citations

humanDrosophila

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GeneticseLifePeer-reviewedJan 1, 2022

Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset

Arian Mansur, Remi Joseph, Euri S Kim…·Vandana Gupta

This study identifies KLHL40 as a negative regulator of ER-Golgi trafficking through ubiquitylation, revealing its role in skeletal muscle development and disease.

19 citations

zebrafishproteomics

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