Aashiq Hussain Kachroo

The paper uses human ORFeome expression in yeast to study conserved mechanisms of extracellular vesicle cargo sorting.

This study develops a humanized yeast model to study TRAPP complex mutations, showing that human TRAPPC1 variants cause secretion and autophagy defects in yeast, mirroring human fibroblast defects.

The paper identifies protein-protein interactions and proteolytic activity as key factors determining the functional replaceability of human proteasome subunits in yeast.

The paper introduces MERGE, a method for marker-less, scalable genome editing in yeast by combining CRISPR-Cas9 and gene drives to efficiently integrate and combine multiple genetic edits.

This study identifies TUBB8 as the molecular target of benzimidazoles, revealing their mechanism of vascular disruption and potential clinical applications.

The paper replaces yeast genes with human orthologs to study functional divergence, finding that replaceability depends on divergence and expression patterns of human co-orthologs.