Simon Zhongyuan Tian

MCIBox is a toolkit for analyzing single-molecule chromatin interactions and identifying micro-domains through visualization and clustering algorithms.

The paper introduces Pore-C, a long-read sequencing method for capturing multi-way chromatin interactions and DNA methylation in Arabidopsis.

This study investigates how PML/RARα alters chromatin topology and transcription in APL cells, revealing its role in repressing myeloid differentiation genes.

The paper introduces MIA-Sig, an algorithm to de-noise chromatin interaction data and identify topological domains and inter-domain contacts.

ChIA-DropBox is a computational pipeline for analyzing ChIA-Drop data, reconstructing chromatin complexes, and visualizing multiplex chromatin interactions.

This paper introduces a method to analyze multiplex chromatin interactions with single-molecule precision and shows they contribute to topologically associated domains and gene regulation.