Jacqueline Jufen Zhu

JACKIE enumerates genomic single- and multi-copy target sites and their off-targets for CRISPR and other nucleases, enabling efficient design and visualization.

This paper introduces a CRISPR-based imaging method to label nonrepetitive genomic loci and track chromatin dynamics in live cells.

This study investigates how PML/RARα alters chromatin topology and transcription in APL cells, revealing its role in repressing myeloid differentiation genes.

The paper uses super-resolution microscopy to visualize a chromatin loop in human cells and validates the results with Hi-C data.

This paper introduces a method to analyze multiplex chromatin interactions with single-molecule precision and shows they contribute to topologically associated domains and gene regulation.