Robin Browaeys

The paper examines systemic immune changes across the CFTR dysfunction spectrum using single-cell immune profiling in pwCF, carriers, and non-carriers, revealing immune signatures linked to CFTR function.

Continued allergen exposure drives lung TLO to generate ASCs that home to IL1-instructed para-bronchial cuffs.

The paper benchmarks 11 cell type deconvolution methods on spatial transcriptomics data using synthetic and real datasets, finding that some off-the-shelf methods outperform specialized ones.

Combining pseudobulk differential expression, cell-type specificity, sample prevalence and NicheNet-v2 ligand activity, MultiNicheNet ranks condition-specific ligand-receptor-target signaling in multi-sample scRNA-seq with batches or multifactor designs.