Simon Jan Tavernier

The paper examines systemic immune changes across the CFTR dysfunction spectrum using single-cell immune profiling in pwCF, carriers, and non-carriers, revealing immune signatures linked to CFTR function.

Combining pseudobulk differential expression, cell-type specificity, sample prevalence and NicheNet-v2 ligand activity, MultiNicheNet ranks condition-specific ligand-receptor-target signaling in multi-sample scRNA-seq with batches or multifactor designs.

Unsupervised trajectory inference by SCORPIUS outperformed Wanderlust, Monocle and Waterfall across ten scRNA-seq datasets and predicted falling protein synthesis during dendritic cell development, validated in vivo.