Takakazu Nakabayashi

This study develops a chemical method to enhance oxidative protein folding within PDIA6 condensates, showing up to 12-fold acceleration in vitro and improved insulin secretion in cells.

This study uses Raman-Brillouin microscopy to show lipids are enriched in heterochromatin and influence its mechanical properties in living cells.

This study shows Ca2+ induces PDIA6 phase separation, enhancing proinsulin folding and preventing aggregation through recruitment of PDIA3.