Author

Mayuko Hashimoto

Frontier Research Institute for Interdisciplinary Sciences, Tohoku University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Kenta AraiiD· 2 shared Mai Watabe· 2 shared Masaki OkumuraiD· 2 shared Takahiro MuraokaiD· 2 shared Takakazu NakabayashiiD· 2 shared Tsubura Kuramochi· 2 shared Airu Takeuchi· 1 shared Eiichiro MoriiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersBioengineering

Kenta AraiORCID

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Author profile →

2 papers

Recent·Most cited

Chemical Boosting of Foldase Condensates Accelerates Oxidative Protein Folding

Mai Watabe, Tsubura Kuramochi, Momoka Fukushima, Misaki Kinoshita, Hiroki Akiba, Kazunori Ban, Mayuko Hashimoto, Noriyuki Uchida, Kenta Arai, Takakazu Nakabayashi, Johannes Büchner, Takahiro Muraoka, Masaki Okumura

This study develops a chemical method to enhance oxidative protein folding within PDIA6 condensates, showing up to 12-fold acceleration in vitro and improved insulin secretion in cells.

bioRxiv · Jul 10, 2026 · PreprintBioengineering

Ca2+-driven PDIA6 phase separation to ensure proinsulin quality control

Young‐Ho Lee, Tomohide Saio, Mai Watabe, Motonori Matsusaki, Shingo Kanemura, Yuxi Lin, Taro Mannen, Tsubura Kuramochi, Yuka Kamada, Katsuya Iuchi, Michiko Tajiri, Kotono Suzuki, Yan Li, Yunseok Heo, Kotone Ishii, , Masaki Okumura

This study shows Ca2+ induces PDIA6 phase separation, enhancing proinsulin folding and preventing aggregation through recruitment of PDIA3.

Nature Cell Biology · Nov 1, 2025Peer-reviewedBiochemistry