Alessandra Pierani

Bidirectional interaction between Protocadherin 8 and transcription factor Dbx1 regulates cerebral cortex development

The paper shows that Protocadherin 8 and Dbx1 interact bidirectionally to regulate cerebral cortex development through changes in neuronal identity and polarity.

Differential contribution of P73+ Cajal-Retzius cells and Reelin to cortical morphogenesis

The paper investigates the role of P73+ Cajal-Retzius cells and Reelin in cortical morphogenesis, finding that CRs-derived Reelin is essential for radial migration arrest, while CRs also have Reelin-independent functions in hippocampal progenitor proliferation and vessel remodelling.

Slitrk/LAR-RPTP and disease-associated variants control neuronal migration in the developing mouse cortex independently of synaptic organizer activity

The paper investigates the role of Slitrk and LAR-RPTP proteins in neuronal migration during mouse cortex development, showing they influence migration independently of synaptic organizer activity.

Repurposing of the multiciliation gene regulatory network in fate specification of Cajal-Retzius neurons

The paper identifies a gene regulatory network involved in multiciliation that is repurposed in the fate specification of Cajal-Retzius neurons, leading to distinct cellular outcomes.

Diversity within olfactory sensory derivatives revealed by the contribution of Dbx1 lineages

The paper shows Dbx1-expressing progenitors in the olfactory epithelium contribute to multiple neuronal lineages, revealing unexpected diversity in their neurogenic potential.

Single-cell transcriptomics of the early developing mouse cerebral cortex disentangles the spatial and temporal components of neuronal fate acquisition

This study uses single-cell RNAseq to analyze progenitor and neuronal diversity in the developing mouse cerebral cortex, revealing how spatial and temporal factors contribute to neuronal fate acquisition.

Functional characterization of RELN missense mutations involved in recessive and dominant forms of Neuronal Migration Disorders

This study functionally characterizes RELN missense mutations in both recessive and dominant neuronal migration disorders, showing a genotype-phenotype correlation.

Extracellular Pax6 regulates tangential Cajal-Retzius cell migration in the developing mouse neocortex

This study shows that extracellular Pax6 non-cell autonomously regulates Cajal-Retzius cell migration in the developing mouse neocortex by affecting directionality, distance, and depth of migration.