Alan J. Tackett

The paper identifies dynamic acetylation changes in yeast during heat shock, showing acetylation regulates protein activity to enhance the heat shock response.

This study shows YY1 enhances p300 acetyltransferase activity in CRPC, promoting histone acetylation and oncogenic gene expression, and identifies a potential therapeutic target for overcoming drug resistance.

This study evaluates the anti-breast cancer activity of monensin and its analogs in organoid models, finding they reduce stem-like cell proliferation and dysregulate stemness markers.

This study investigates how melanoma cells respond to methionine restriction by comparing methionine-dependent and -independent cell lines, revealing differences in methylation, transcriptome, and proteome responses.

The paper presents a proteogenomic approach to identify resistance-specific alterations in melanoma PDX models treated with MAPK inhibitors using custom curated databases.

The paper quantifies the dynamic heat shock proteome in budding yeast using TMT-MS3, revealing differential protein expression and PTM regulation over time.

The paper uses metaproteomics to analyze cecum contents in CKD rats with and without resistant starch, revealing shifts in gut microbiota and host proteins associated with improved CKD outcomes.