Author

Karla C. Williams

University of British ColumbiaORCID 0000-0003-2954-2869Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Merlyn Emmanuel· 2 shared Boxon Zhang· 1 shared Brent D. G. PageiD· 1 shared Chloe A.K. White· 1 shared Esther Afolalan· 1 shared Esther Afolayan· 1 shared Jacob MelamediD· 1 shared Kendal Ruzicki· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

Merlyn Emmanuel

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintNov 17, 2025

DMEM, or Opti-MEM, that is the Question: An Important Consideration for Extracellular Vesicle Isolation and their Downstream Applications.

Nikki Salmond, Jacob Melamed, Sina Halvaei, Karla C. Williams

This study compares EV release and composition in different media, finding that Opti-MEM promotes more EV release and distinct pathway usage compared to EV-DEP DMEM.

DOI 10.1101/2025.11.17.683537

humanproteomics

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Cancer BiologybioRxivPreprintOct 15, 2025

Invadopodia-Mediated Remodeling of the Lymphatic Endothelium Drives Cancer Cell Lymphatic Dissemination and is Regulated by a CCR7-Vav2-Rac3 Signaling axis.

Sumreen Javed, Merlyn Emmanuel, Xuewei Chen…·Karla C. Williams

DOI 10.1101/2025.10.15.682688

mousehuman

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Cancer BiologybioRxivPreprintOct 3, 2025

GABA-GABA_A Receptor Signaling Orchestrates Invasion and Metastasis in Triple Negative Breast Cancer

Esther Afolayan, Boxon Zhang, Mingde Han…·Karla C. Williams

This study shows that GABA signaling via GABAA receptors promotes invasion and metastasis in triple-negative breast cancer.

DOI 10.1101/2025.10.03.674636

humanexperimental assay

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