NeurosciencebioRxivPreprint
A novel mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein fibrils and recapitulates its pathological diversity
Senthil T. Kumar, Anne‐Laure Mahul‐Mellier, Ramanath Narayana Hegde…·Hilal Ahmed Lashuel
The paper investigates the effects of the E83Q mutation on alpha-synuclein aggregation and toxicity, finding it accelerates fibrillization and enhances pathological features in neuronal models.
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