Author

Ramanath Narayana Hegde

École Polytechnique Fédérale de LausanneORCID 0000-0001-7224-3544Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Hilal Ahmed LashueliD· 3 shared Anass ChikiiD· 2 shared Anne‐Laure Mahul‐MellieriD· 2 shared Pedro MagalhãesiD· 2 shared Sonia Donzelli· 2 shared Ahmed SadekiD· 1 shared Alain Ibáñez de OpakuaiD· 1 shared Andrea CaricasoleiD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersNeuroscience

Hilal Ahmed LashuelORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintMar 30, 2022

Neighbouring modifications interfere with the detection of phosphorylated alpha-synuclein at Serine 129: Revisiting the specificity of pS129 antibodies

Hilal Ahmed Lashuel, Anne‐Laure Mahul‐Mellier, Salvatore Novello…·Nicolas Guex

The paper shows that neighboring post-translational modifications affect the detection of phosphorylated alpha-synuclein at Serine 129 by existing antibodies.

2 citations

mouseproteomics

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NeurosciencebioRxivPreprintNov 21, 2021

A novel mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein fibrils and recapitulates its pathological diversity

Senthil T. Kumar, Anne‐Laure Mahul‐Mellier, Ramanath Narayana Hegde…·Hilal Ahmed Lashuel

The paper investigates the effects of the E83Q mutation on alpha-synuclein aggregation and toxicity, finding it accelerates fibrillization and enhances pathological features in neuronal models.

3 citations

humanproteomics

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NeurosciencebioRxivPreprintDec 10, 2019

TBK1 regulates autophagic clearance of soluble mutant huntingtin and inhibits aggregation/toxicity in different models of Huntington's disease

Ramanath Narayana Hegde, Anass Chiki, Lara Petricca…·Hilal Ahmed Lashuel

This study identifies TBK1 as a kinase that phosphorylates mutant huntingtin, reduces its aggregation and toxicity in multiple HD models.

2 citations

C. eleganshuman

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