Author

Jennifer C. Darnell

Simons Initiative for the Developing BrainORCID 0000-0003-2966-3249Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Kirsty SawickaiD· 2 shared Callista B. HarperiD· 1 shared Chaolin ZhangiD· 1 shared Chingwen Yang· 1 shared Christopher Y. ParkiD· 1 shared Ellen C. GingrichiD· 1 shared Emily K. OsterweiliD· 1 shared John J. FakiD· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Kirsty SawickaORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintApr 7, 2022

Excess ribosomal protein production unbalances translation in Fragile X Syndrome

Sang S. Seo, Susana R. Louros, Natasha J. Anstey…·Emily K. Osterweil

The paper identifies excessive ribosomal protein translation as a key factor in Fragile X Syndrome by showing its role in disrupting synaptic protein translation and LTD.

DOI 10.1101/2022.04.07.487442

mouseproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintSep 9, 2019

FMRP binding to a ranked subset of long genes is revealed by coupled CLIP and TRAP in specific neuronal cell types

Sarah J. Van Driesche, Kirsty Sawicka, Chaolin Zhang…·Jennifer C. Darnell

The paper develops a mouse model to identify FMRP mRNA targets in specific neurons, revealing that FMRP binds to a ranked subset of long genes related to Fragile X phenotypes.

17 citations

mousescRNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 5, 2018

FMRP association with and regulation of Fragile X granules exhibit circuit-dependent requirements for the KH2 RNA binding domain

Ellen C. Gingrich, Katherine A. Shepard, Molly E. Mitchell…·Michael R. Akins

This study investigates how a mutation in FMRP's KH2 domain affects FXG association and abundance in different brain regions, revealing circuit-dependent regulation mechanisms.

3 citations

mouseexperimental assay

𝕏 PostBluesky