Susana R. Louros

FMR1 gene therapy restores activity-driven inhibition and prevents audiogenic seizures in Fmr1-/y mice

This study shows that AAV-FMR1 gene therapy restores auditory circuit function and prevents audiogenic seizures in Fmr1-/y mice by normalizing translation and excitatory/inhibitory balance in the inferior colliculus.

Excess ribosomal protein production unbalances translation in Fragile X Syndrome

The paper identifies excessive ribosomal protein translation as a key factor in Fragile X Syndrome by showing its role in disrupting synaptic protein translation and LTD.

Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability

This study shows that a stargazin mutation causes cognitive and synaptic defects in mice, linking it to intellectual disability.

Functional Predictors of Causative Cis-Regulatory Mutations in Mendelian Disease

The paper identifies rare CRE variants associated with X-linked intellectual disability by combining sequencing, functional assays in zebrafish and mice, and phenotypic analysis.

Lovastatin, not simvastatin, corrects core phenotypes in the fragile X mouse model

This study compares lovastatin and simvastatin in a fragile X mouse model, finding lovastatin corrects neurological phenotypes while simvastatin does not.