Author

Magdalena Zwierzyna

University College LondonORCID 0000-0002-7445-6030Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Assay:GWAS summary statistics· 2 Approach:experimental assay· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Aroon Dinesh HingoraniiD· 3 shared Amand Floriaan SchmidtiD· 2 shared Chris FinaniD· 2 shared María Gordillo‐MarañóniD· 2 shared Sandesh ChopadeiD· 2 shared Alun David HughesiD· 1 shared Andrea M. A. SchreijiD· 1 shared Andreas BeyeriD· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersGenetics

Aroon Dinesh HingoraniORCID

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Author profile →

4 papers

Recent·Most cited

RNA folding using quantum computers

Dillion M. Fox, Christopher M. MacDermaid, Andrea M. A. Schreij, Magdalena Zwierzyna, Ross C. Walker

This paper uses quantum computing to predict RNA secondary structure, showing it is competitive with classical methods in finding low-energy solutions.

PLoS Computational Biology · Apr 11, 2022Peer-reviewedBioinformatics

Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics

María Gordillo‐Marañón, Magdalena Zwierzyna, Pimphen Charoen, Fotios Drenos, Sandesh Chopade, Tina Shah, Jorgen Engmann, Nish Chaturvedi, Olia Papacosta, S. Goya Wannamethee, Andrew Wong, Reecha Sofat, Mika Kivimaki B, Jackie F. Price, Alun David Hughes, , Chris Finan

The paper uses Mendelian randomization and clinical/biological evidence to prioritize lipid-modifying drug targets for coronary heart disease prevention.

Nature Communications · Oct 21, 2021Peer-reviewedGenetics

Biological mechanisms of aging predict age-related disease multimorbidities in patients

Helen C. Fraser, Valerie Kuan, Ronja Johnen, Magdalena Zwierzyna, Aroon Dinesh Hingorani, Andreas Beyer, Linda Partridge

The paper identifies aging mechanisms that predict age-related disease multimorbidities in humans using literature analysis and clinical data integration.

bioRxiv · May 4, 2021 · PreprintBioinformatics

Genetic drug target validation using Mendelian randomization

Amand Floriaan Schmidt, Chris Finan, María Gordillo‐Marañón, Folkert Wouter Asselbergs, Daniel F. Freitag, Riyaz S. Patel, Benoît Tyl, Sandesh Chopade, Rupert Faraway, Magdalena Zwierzyna, Aroon Dinesh Hingorani

This paper introduces a mathematical framework to improve Mendelian randomization analysis for drug targets by addressing horizontal pleiotropy when proteins are the risk factors.

bioRxiv · Sep 25, 2019 · PreprintGenetics