GeneticsFrontiers in AgingPeer-reviewed
Endosomal trafficking protein TBC-2 isrequired for the longevity of long-livedmitochondrial mutants
Annika Traa, Hazel J. Shields, Abdelrahman AlOkda…·Jeremy M. Van Raamsdonk
This study shows that disrupting TBC-2 reduces lifespan and stress resistance in long-lived mitochondrial mutants in C. elegans, suggesting a role for endosomal trafficking in mitochondrial dysfunction-related longevity.
DOI 10.3389/fragi.2023.1145198