Abdelrahman AlOkda

Elevated mitochondrial superoxide promotes longevity through a mitochondria-to-nucleus kinase signaling pathway

This study identifies a mitochondria-to-nucleus kinase signaling pathway that promotes longevity in sod-2 mutants by upregulating innate immunity and cuticle formation genes.

Cyrene: A Novel Geroprotective Compound that Extends Lifespan and Healthspan in C. elegans and Drosophila

This paper identifies Cyrene as a geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila, improving stress resistance and neuroprotection.

Mild activation of the mitochondrial unfolded protein response increases lifespan without increasing resistance to stress

This study shows that mild activation of the mitochondrial unfolded protein response (mitoUPR) through ATFS-1 can increase lifespan without enhancing stress resistance in worms.

Endosomal trafficking protein TBC-2 isrequired for the longevity of long-livedmitochondrial mutants

This study shows that disrupting TBC-2 reduces lifespan and stress resistance in long-lived mitochondrial mutants in C. elegans, suggesting a role for endosomal trafficking in mitochondrial dysfunction-related longevity.