Author

Zenith D. Rudich

Research Institute of the McGill University Health Centre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetics· 3 Developmental Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:C. elegans· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2

Frequent Co-Authors

Jeremy M. Van RaamsdonkiD· 4 shared Annika TraaiD· 3 shared Meeta MistryiD· 2 shared Sonja K. Soo· 2 shared Abdelrahman AlOkdaiD· 1 shared Alibek MoldakozhayeviD· 1 shared Allison T. KeiliD· 1 shared Aura A Tamez González· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersGenetics

Jeremy M. Van RaamsdonkORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies

Zenith D. Rudich, Jiaxi Guan, Aura A Tamez González, Grant F Booth, Sonja K. Soo, Ulrich Anglas, Meeta Mistry, Megan M. Senchuk, Jeremy M. Van Raamsdonk

This study identifies 196 upregulated and 62 downregulated aging genes across long-lived C. elegans mutants, revealing distinct gene expression strategies for longevity.

bioRxiv · Jul 21, 2026 · PreprintGenetics

Overexpression of mitochondrial fusion genes enhances resilience and extends longevity

Annika Traa, Allison T. Keil, Zenith D. Rudich, Shusen Zhu, Jeremy M. Van Raamsdonk

This study shows that overexpressing mitochondrial fission or fusion genes increases lifespan and stress resistance in C. elegans, despite causing mitochondrial fragmentation.

bioRxiv · Oct 24, 2023 · PreprintDevelopmental Biology

Endosomal trafficking protein TBC-2 isrequired for the longevity of long-livedmitochondrial mutants

Annika Traa, Hazel J. Shields, Abdelrahman AlOkda, Zenith D. Rudich, Bokang Ko, Jeremy M. Van Raamsdonk

This study shows that disrupting TBC-2 reduces lifespan and stress resistance in long-lived mitochondrial mutants in C. elegans, suggesting a role for endosomal trafficking in mitochondrial dysfunction-related longevity.

Frontiers in Aging · May 16, 2023Peer-reviewedGenetics

Genetic basis of enhanced stress resistance in long-lived mutants highlights key role of innate immunity in determining longevity

Sonja K. Soo, Annika Traa, Zenith D. Rudich, Alibek Moldakozhayev, Meeta Mistry, Jeremy M. Van Raamsdonk

The paper examines nine long-lived C. elegans mutants to show a strong correlation between stress resistance and longevity, driven by overlapping genetic pathways.

Aging Cell · Dec 13, 2022Peer-reviewedGenetics