Rui Huang

This study analyzes CRISPR spacer number evolution in bacteria, finding correlations with repeat length, polymorphism, and immune demand, and identifying degenerative patterns in obsolete arrays.

The paper identifies AC9 as a key regulator of ER calcium homeostasis during neuronal differentiation using CRISPR screening and functional analysis.

The paper identifies a genetic modifier locus, Bphse, that complements resistance to histamine sensitization in mice by analyzing Hrh1 alleles and using network-based methods.

The paper uses network-based functional prediction to prioritize candidate genes in a mouse histamine hypersensitivity QTL, identifying genes with strong functional associations and SNP proximity.