Youjun Wang

The paper uses AlphaFold3 to analyze STIM autoinhibition in human and C. elegans, revealing conserved and species-specific structural features.

The paper introduces NEMOer, a set of genetically encoded calcium indicators that enhance the detection of ER/SR calcium dynamics, enabling sensitive and dynamic imaging in both excitable and non-excitable cells.

This study identifies glucosidase II as a regulator of STIM1 activation dynamics by modulating Ca2+ binding affinity and influencing store-operated Ca2+ entry.

The paper identifies AC9 as a key regulator of ER calcium homeostasis during neuronal differentiation using CRISPR screening and functional analysis.

This paper develops NEMO, a new suite of calcium indicators with higher sensitivity and dynamic range than existing GECIs, enabling better detection of calcium transients in neurons and other cells.