Francisco A. Cubillos

This study examines genomic and phenotypic diversity in Yarrowia lipolytica, showing how specialization and admixture drive adaptation to different environments and industrial traits.

This study shows that host-shift adaptation in S. eubayanus leads to genomic changes, particularly structural variants, linked to sugar metabolism and host-specific traits.

This study shows that S. eubayanus adapts to long-term cold starvation through transcriptional reprogramming, not genetic mutations, leading to improved cryotolerance and growth.

This study investigates the role of a horizontally acquired genomic region in yeast adaptation by analyzing its molecular and phenotypic effects across different genetic backgrounds.

The paper identifies allelic variation in MAL33 as a driver of ecological adaptation in maltose metabolism among Saccharomyces eubayanus strains.

The paper identifies genomic modifiers of neurological resilience in Niemann-Pick C disease by analyzing exomes from a family with diverse phenotypes and validates findings in yeast models.

This study examines how genetic variants in Saccharomyces cerevisiae affect paraquat toxicity, finding strain-specific differences in growth, oxidative stress, and vacuolar responses.

This study investigates hybridization success and fermentation traits in lager yeast hybrids, finding that parental lineages influence volatile compound profiles and phenotypic variability.

The paper identifies a new Saccharomyces species, S. chiloensis sp. nov., using integrative taxonomy methods, showing genetic and reproductive divergence from S. uvarum.

This study improves Lager yeast hybrids using wild Patagonian S. eubayanus strains, revealing genetic factors that enhance fermentation and aroma profiles.

This study identifies structural variants in a domesticated Lachancea cidri yeast strain associated with improved fermentation traits compared to wild isolates.

The paper identifies cis regulatory variants affecting gene expression and chromatin accessibility in yeast under nitrogen scarcity by analyzing an F1 hybrid of two strains.

This study uses experimental evolution to simulate the domestication of wild yeast under brewing conditions, showing rapid genetic and phenotypic changes in response to ethanol selection.

The paper constructs a deep transformer model to predict gene expression from cis-regulatory DNA sequences in yeast, revealing evolutionary constraints and evolvability patterns.

The paper analyzes the genetic distribution of Saccharomyces eubayanus and finds that Patagonian lineages likely originated the species, which then dispersed globally.