Matteo De Chiara

The paper quantifies mating strategies in yeast gametes, revealing a reproductive hierarchy where sibling gametes have divergent mating trajectories and temporal heterogeneity shapes compatibility.

This study reprograms yeast telomeres to human-like sequences and identifies adaptive mutations that allow survival and fitness recovery.

This study investigates the role of a horizontally acquired genomic region in yeast adaptation by analyzing its molecular and phenotypic effects across different genetic backgrounds.

This study uses optogenetics to show that region A genes in wine yeast are essential for completing fermentation under low nitrogen conditions.

The paper identifies a new Saccharomyces species, S. chiloensis sp. nov., using integrative taxonomy methods, showing genetic and reproductive divergence from S. uvarum.

The paper quantifies proteomic effects of aneuploidy in natural yeast isolates, finding chromosome-wide dosage compensation in the proteome but not transcriptome.

This study uses machine learning to predict yeast phenotypes from genotypes, finding gradient boosting machines perform best and accessory genome contributes significantly.

This paper presents 142 high-quality yeast genomes to improve pangenome understanding, identifying structural variants and complex genomic regions.

The paper finds that wild Saccharomyces cerevisiae isolates have shorter telomeres than domesticated ones, linked to genetic and metabolic differences.

The paper identifies miRNA copy number variations as a marker for cancer predisposition across species, showing they can distinguish cancer-prone from cancer-resistant organisms.

Aborting meiosis followed by return-to-growth promotes genome-wide recombination in sterile yeast hybrids, enabling adaptation and genetic mapping.

CRISpy-pop designs and predicts CRISPR/Cas9 guide RNA activity across diverse yeast and bacterial strains, including human genome cross-referencing for biosafety.

The paper analyzes mitochondrial and nuclear genomes of Saccharomyces cerevisiae to show discordant evolutionary patterns between the two genomes.

The paper analyzes the genetic distribution of Saccharomyces eubayanus and finds that Patagonian lineages likely originated the species, which then dispersed globally.