Wanglong Zheng

G4 Eurasian avian-like H1N1 swine influenza viruses exhibit enhanced pathogenicity potential in mice and pigs

This study isolates and analyzes two G4 Eurasian avian-like H1N1 swine influenza viruses, showing they have enhanced pathogenicity in mice and pigs due to molecular features like HA receptor affinity and polymerase activity.

ASFV early protein p30 suppresses antiviral type I IFN induction by targeting TRIM21 and RIG-I like receptor signaling adaptor MAVS

This study identifies ASFV p30's role in suppressing antiviral type I IFN induction by interacting with TRIM21 and MAVS, disrupting TRIM21-mediated K27 polyubiquitination of MAVS.

Species-specific regulation of porcine STING stability and antiviral signaling via its K61 mediated K48 ubiquitination and proteasome degradation

This study identifies K61-mediated K48 ubiquitination and proteasome degradation of porcine STING as a species-specific mechanism regulating antiviral signaling.

Chicken IRF10 suppresses the cGAS-STING-IFN antiviral signaling pathway by targeting IRF7

This study identifies chIRF10 as a suppressor of chicken cGAS-STING-IFN antiviral signaling by inhibiting chIRF7 activation and dimerization.

PRRSV evades innate immune cGAS-STING antiviral function via its Nsp5 to deter STING translocation and activation

This study identifies PRRSV's Nsp5 protein as a mechanism to inhibit the cGAS-STING-IFN antiviral pathway by blocking STING translocation and activation, thereby promoting viral replication.