Huibing Zhang

This study reveals the constitutive activity and dimerization mechanism of GPR156, explaining its role in auditory function through cryo-EM structures and functional analysis.

The paper reports the structures of galanin bound to its receptors and G proteins, revealing the molecular basis for allosteric agonism and G protein subtype selectivity.

The paper identifies a splice variant of the GHRHR receptor that mediates constitutive signal bias towards β-arrestin recruitment, impacting downstream signaling pathways in prostate cancer cells.

The paper reports high-resolution structures of MC4R with agonists and reveals insights into ligand recognition and activation mechanisms.

The paper reports the structures of D1R-Gs complex bound to dopamine and LY3154207, revealing mechanisms of dopamine recognition and allosteric modulation for drug discovery.