Hualiang Jiang

This study shows that FMRP phosphorylation regulates neuronal translation via YTHDF1, revealing a mechanism for FXS pathology and suggesting YTHDF1 as a therapeutic target.

The paper identifies a conserved carbohydrate-recognition motif in purinergic receptors and demonstrates its role in activating GPCRs through sugar nucleotide binding.

The paper presents cryo-EM structures of endothelin receptors bound to ligands, revealing their recognition mode and activation mechanism.

The paper reports the structures of TSHR activated by TSH and an autoantibody, revealing a universal activation mechanism and the role of cholesterol in TSHR localization.

This paper introduces a sequence-to-drug paradigm using TransformerCPI2.0 to discover drug-like molecules from protein sequences and validates its effectiveness for three targets.

The paper reports the structures of galanin bound to its receptors and G proteins, revealing the molecular basis for allosteric agonism and G protein subtype selectivity.

AutoGGN integrates multi-omics data and molecular interaction networks using graph convolutional neural networks, achieving better performance in cancer and single-cell classification tasks.

The paper identifies a splice variant of the GHRHR receptor that mediates constitutive signal bias towards β-arrestin recruitment, impacting downstream signaling pathways in prostate cancer cells.

The paper reports cryo-EM structures of LHCGR in different activation states, revealing a push and pull mechanism of receptor activation and the role of an allosteric agonist.

The paper reports the structures of D1R-Gs complex bound to dopamine and LY3154207, revealing mechanisms of dopamine recognition and allosteric modulation for drug discovery.

The paper discovers suramin as a potent inhibitor of SARS-CoV-2 RNA polymerase and provides its structural mechanism for repurposing in treating COVID-19.

This paper develops a deep learning system to design multitarget antipsychotic drugs, generating novel compounds with activity against multiple receptors and demonstrating efficacy in animal models.

This study reports the structure of SARS-CoV-2 RdRp with and without Remdesivir, showing how the drug inhibits viral RNA replication by terminating chain elongation.

Baicalin and baicalein from Scutellaria baicalensis inhibit SARS-CoV-2 3CL protease non-covalently; a 2.2 Å baicalein complex structure shows an unusual shield-like binding mode.

The paper introduces a Siamese spectral-based graph convolutional network to infer protein targets of chemical compounds from gene expression data, achieving better performance than existing methods.