Lev Litichevskiy

This study shows that diet can significantly affect survival in a mouse model of Hirschsprung disease by altering gut microbes, metabolites, and epithelial gene expression.

In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.

The paper shows acetate supplementation improves social deficits and changes gene expression in the prefrontal cortex of Shank3-deficient mice.

The paper compares morphology and gene expression data to determine their complementary roles in mapping cell states across drug perturbations.

The paper creates a proteomic resource profiling 90 drugs in six cell lines, revealing cell-specific responses and enabling integration with transcriptional data to identify therapeutic opportunities.

The paper introduces the GCTx format and associated software packages for efficiently storing and analyzing large dense matrices of perturbation data and annotations.