Maigan Brusko

Divergent chromatin remodeling in post-sepsis MDSCs underlies MHC class II repression in CCI

The paper profiles chromatin accessibility in post-sepsis MDSCs, showing divergent epigenetic trajectories between rapid recovery and chronic critical illness, with MHC class II repression in CCI.

Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes

This study uses spatial transcriptomics to identify inflammation signatures in pancreas and lymph node tissues of T1D patients, highlighting LTB and other genes involved in disease pathogenesis.

3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes

The paper uses 3D imaging to analyze pancreatic islets in healthy and type 1 diabetes (T1D) individuals, finding that islet size and composition influence their loss in T1D.

Age- and Sex- Driven Transcriptional and Metabolic Diversity in Myeloid-Derived Suppressor Cells After Mouse Sepsis

This study examines age and sex effects on MDSCs in sepsis using single-cell RNA sequencing, finding differences in expansion, transcriptome, and metabolism.

Aberrant immune regulation and enrichment of stem-like CD8+ T cells in the pancreatic lymph node during type 1 diabetes development

This study identifies aberrant immune regulation and stem-like CD8+ T cells in pancreatic lymph nodes during type 1 diabetes development using mass cytometry and single-cell RNA sequencing.

Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas Construction and Usage

This paper describes the construction and usage of the Human Reference Atlas (HRA) v2.0, which integrates multiscale data across 36 organs and provides tools for analysis and visualization.

Imaging mass cytometry reveals early β-cell dysfunction and changes in immune signatures during type 1 diabetes progression in human pancreata

The paper uses imaging mass cytometry to analyze human pancreatic samples and identifies early β-cell dysfunction and immune changes in type 1 diabetes progression.

Transcriptional control of T cell tissue adaptation and effector function in infants and adults

This study compares transcriptional profiles of memory T cells in infants and adults to identify age-specific regulatory mechanisms.

Characterizing cell-type spatial relationships across length scales in spatially resolved omics data

The paper introduces CRAWDAD, a tool for analyzing cell-type spatial relationships across scales in spatially resolved omics data, and demonstrates its application on simulated and real datasets.

Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function

This study shows that blocking CD226 reduces diabetes in NOD mice by enhancing Treg function and reducing effector T cell activity.

Data-driven selection of analysis decisions in single-cell RNA-seq trajectory inference

The paper introduces Escort, a framework to evaluate dataset suitability for trajectory inference and quantify trajectory properties, reducing analysis uncertainty through data-driven assessments.

geneBasis: an iterative approach for unsupervised selection of targeted gene panels from scRNA-seq.

geneBasis selects an optimal gene panel from scRNA-seq data by iteratively adding genes that maximize manifold distance, outperforming existing methods in resolving cell types and states.