ImmunologybioRxivPreprint
Asymmetric Boost Responses to an HIV-1 Vaccine: Boost-site Controls Secondary B-cell Fates
John S. Barber, Keisuke Tonouchi, Chen‐Hao Yeh…·Garnett H. Kelsoe
The paper shows that boosting at the same site as the initial immunization preferentially engages bnAb lineage precursors in secondary germinal centers, while contralateral boosting recruits naive and non-specific memory B cells.