G-quadruplex targeting by CX-5461 as a novel therapeutic strategy in testicular germ cell tumors
Rashidul Islam, Annalena Liesen, Carlos Saúl Rodríguez-Roque…·Hubert Schorle
This study evaluates G4-ligands in TGCTs, finding CX-5461 induces p53-dependent cell death by stabilizing G4s and disrupting RNA polymerase I transcription.