Hinke G. Kazemier

This study shows disease-related short tandem repeats relocate to nuclear pore complexes, with implications for genome stability and repeat dynamics.

The paper identifies a threshold telomere length in telomerase-negative cells that triggers replicative senescence and genomic instability through dysfunction of the shortest telomere.

The paper identifies HDAC4 as a synthetic lethal target in MELK-overexpressing cancers through a yeast screen and mammalian validation.

The paper identifies genes that suppress spontaneous mutation accumulation in yeast cells, finding PEX19 as an age-specific mutation suppressor.

The paper identifies DHX36 binding to G-rich mRNA regions and shows it reduces mRNA stability without increasing translation.