Author

Annalena Liesen

University Hospital BonnORCID 0009-0009-1204-2092Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Hubert SchorleiD· 2 shared Rashidul IslamiD· 2 shared Amir Shalan· 1 shared Andjela KovaceviciD· 1 shared Anne Wladhaus· 1 shared Carlos Saúl Rodríguez-RoqueiD· 1 shared Gina Esther MergesiD· 1 shared Glen KristianseniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Hubert SchorleORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 20, 2026

XPO1 Inhibition by Selinexor Induces Nuclear p53 and p21 Accumulation, Cell-Cycle Arrest and Apoptosis in Testicular Germ Cell Tumors

Rashidul Islam, Anne Wladhaus, Isabella Federica Bollen…·Hubert Schorle

This study shows selinexor, an XPO1 inhibitor, reduces viability and induces cell-cycle arrest and apoptosis in testicular germ cell tumors by increasing nuclear p53 and p21.

DOI 10.64898/2026.09.14.750914

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintSep 9, 2026

G-quadruplex targeting by CX-5461 as a novel therapeutic strategy in testicular germ cell tumors

Rashidul Islam, Annalena Liesen, Carlos Saúl Rodríguez-Roque…·Hubert Schorle

This study evaluates G4-ligands in TGCTs, finding CX-5461 induces p53-dependent cell death by stabilizing G4s and disrupting RNA polymerase I transcription.

DOI 10.64898/2026.09.04.749562

humanDNA methylation

𝕏 PostBluesky