Author

Heather M. Brechbuhl

University of Colorado Cancer CenterORCID 0000-0003-3132-4465Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

Carol A. SartoriusiD· 3 shared Peter KabosiD· 3 shared Amy HaniD· 2 shared Ashley V. WardiD· 2 shared Kiran Vinod-PauliD· 2 shared Srinivas RamachandraniD· 2 shared Andrew E. LibbyiD· 1 shared Angelo D’AlessandroiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

Carol A. SartoriusORCID

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3 papers

Recent·Most cited

Cancer BiologyBreast Cancer ResearchPeer-reviewedMar 7, 2025

Lipid metabolic reprogramming drives triglyceride storage and variable sensitivity to FASN inhibition in endocrine-resistant breast cancer cells

Ashley V. Ward, Duncan Riley, Kirsten E. Cosper…·Carol A. Sartorius

This study identifies lipid metabolic reprogramming in endocrine-resistant breast cancer cells, showing TVB-2640 reduces lipid storage but not cell growth.

21 citationstop 2%

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintDec 28, 2024

Metabolic Switch in Endocrine Resistant Estrogen Receptor Positive Breast Cancer

Heather M. Brechbuhl, Amy Han, Kiran Vinod-Paul…·Peter Kabos

This study investigates how metabolic changes in endocrine-resistant ER+ breast cancer cells affect ER DNA-binding patterns and shows that DMF can restore sensitivity to endocrine therapies by targeting metabolic vulnerabilities.

4 citations

humanmetabolomics

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Molecular BiologybioRxivPreprintSep 23, 2022

Estradiol (E2) concentration shapes the chromatin binding landscape of the estrogen receptor

Amy Han, Kiran Vinod-Paul, Satyanarayan Rao…·Peter Kabos

The paper shows that estradiol concentration changes the chromatin binding sites of the estrogen receptor, affecting its localization and interaction with DNA motifs.

1 citation

humanChIP-seq

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