Alessandra Balduini

This study shows that silencing fibronectin reduces fibrotic bone marrow niche remodeling and stromal activation in myelofibrosis models.

This study uses a genetic anemia model to show that reduced thrombopoietin affects hematopoietic stem cells and the bone marrow niche through direct and indirect mechanisms.

This study uses CRISPR/Cas9 to delete Shp1 and Shp2 in human CD34+ cells, showing Shp2 is critical for megakaryopoiesis and thrombopoiesis while Shp1 is not.

This study shows that a bioprinted silk marrow niche supports proper megakaryopoiesis and reduces DNA damage compared to 2D culture under genotoxic stress.

The paper identifies SEL1L's role in platelet function across species, showing it is necessary for platelet adhesion to injured sites.