Cell BiologybioRxivPreprint
CRISPR/Cas9-mediated deletion of Shp1 and Shp2 reveals distinct roles in human megakaryopoiesis and proplatelet formation
Eugénie Schaeffer, Elsa Barré, Desline Hennequin…·Alexandra Mazharian
This study uses CRISPR/Cas9 to delete Shp1 and Shp2 in human CD34+ cells, showing Shp2 is critical for megakaryopoiesis and thrombopoiesis while Shp1 is not.
DOI 10.64898/2026.07.23.735226