Author

Christian Andrea Di Buduo

University of PaviaORCID 0000-0002-6472-2008Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

Alessandra BalduiniiD· 2 shared Alessandro MalaraiD· 1 shared Alexandra MazharianiD· 1 shared Catherine StrasseliD· 1 shared Cécile Loubière· 1 shared Claudia Del FanteiD· 1 shared Desline HennequiniD· 1 shared Elin Pernevik· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

Alessandra BalduiniORCID

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2 papers

Recent·Most cited

CRISPR/Cas9-mediated deletion of Shp1 and Shp2 reveals distinct roles in human megakaryopoiesis and proplatelet formation

Eugénie Schaeffer, Elsa Barré, Desline Hennequin, Cécile Loubière, Léa Mallo, Catherine Strassel, Christian Andrea Di Buduo, Alessandra Balduini, Yotis A. Senis, Alexandra Mazharian

This study uses CRISPR/Cas9 to delete Shp1 and Shp2 in human CD34+ cells, showing Shp2 is critical for megakaryopoiesis and thrombopoiesis while Shp1 is not.

bioRxiv · Jul 24, 2026 · PreprintCell Biology

A bioprinted silk marrow niche reveals mechanical regulation of human megakaryopoiesis under genotoxic stress

Christian Andrea Di Buduo, Matteo Migliavacca, Michele Menotta, Elin Pernevik, Alessandro Malara, Santo Diprima, Giovanni Goggi, Claudia Del Fante, Monica Savio, Volodymyr Kuzmenko, Mauro Magnani, Alessandra Balduini

This study shows that a bioprinted silk marrow niche supports proper megakaryopoiesis and reduces DNA damage compared to 2D culture under genotoxic stress.

bioRxiv · Jun 19, 2026 · PreprintCell Biology