Author
Broad InstituteORCID 0000-0003-3150-4052Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Alexandre Emond, Carl Laflamme, Martine Therrien…·J. Alex Parker
The paper develops a zebrafish C9orf72 knockout model for ALS, identifies pizotifen malate as a potential therapeutic, and validates its efficacy in both zebrafish and C. elegans models.
Francesco Limone, Daniel A. Mordes, Alexander Couto…·Kevin C. Eggan
The paper identifies cell type-specific molecular changes in ALS patients, showing enrichment of genetic risk factors in extratelencephalic neurons and altered responses in oligodendrocytes and microglia.
Michael-John Dolan, Martine Therrien, Saša Jereb…·Beth Stevens
This paper develops a platform to model and manipulate human microglial states in vitro using single-cell RNA sequencing and genetic tools, identifying disease-associated transcriptional signatures.
Vahid Gazestani, Tushar Kamath, Naeem M. Nadaf…·Evan Z. Macosko
The paper identifies a transient hyperactive neuronal state in early Alzheimer's disease using single-nucleus transcriptomics from living patients.