Author

Alexander Couto

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Brian J. JosephiD· 2 shared Daniel MeyeriD· 2 shared Francesco LimoneiD· 2 shared Jana M. MitchelliD· 2 shared Kevin C. EgganiD· 2 shared Olli P. H. PietiläineniD· 2 shared Steven A. McCarrolliD· 2 shared Sulagna Dia GhoshiD· 2 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Brian J. JosephORCID

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2 papers

Recent·Most cited

Single-nucleus sequencing reveals enriched expression of genetic risk factors in Extratelencephalic Neurons sensitive to degeneration in ALS

Francesco Limone, Daniel A. Mordes, Alexander Couto, Brian J. Joseph, Jana M. Mitchell, Martine Therrien, Sulagna Dia Ghosh, Daniel Meyer, Yingying Zhang, Melissa Goldman, Laura Bortolin, Inma Cobos, Beth Stevens, Steven A. McCarroll, Irena Kadiu, , Kevin C. Eggan

The paper identifies cell type-specific molecular changes in ALS patients, showing enrichment of genetic risk factors in extratelencephalic neurons and altered responses in oligodendrocytes and microglia.

Nature Aging · Jun 21, 2024Peer-reviewedNeuroscience

Efficient generation of lower induced Motor Neurons by coupling Ngn2 expression with developmental cues

Francesco Limone, Irune Guerra San Juan, Jana M. Mitchell, Janell L.M. Smith, Kavya Raghunathan, Daniel Meyer, Sulagna Dia Ghosh, Alexander Couto, Joseph R. Klim, Brian J. Joseph, John T. Gold, Curtis J. Mello, James C. Nemesh, Brittany M. Smith, Matthijs Verhage, , Kevin C. Eggan

This study combines Ngn2 overexpression with small molecule patterning to efficiently generate lower induced Motor Neurons (liMoNes) from hPSCs, achieving high yields and functional characteristics.

Cell Reports · Jan 1, 2023Peer-reviewedNeuroscience