Pauline Juyoux

The paper determines cryo-EM structures of MEK1 activating ERK2, elucidating specificity and activation mechanisms in the MAPK pathway.

The paper shows that MAP2Ks can phosphorylate and activate MAPKs using ADP in vitro, suggesting a potential role in maintaining signaling under ATP-depleted conditions.

The paper describes metal fluorides as tools for studying phosphoryl transfer enzymes, highlighting their use in structural biology techniques and introducing scandium tetrafluoride as a new analog.

This study reveals the structural mechanism of MCIA complex assembly, showing how ECSIT and ACAD9 interact to facilitate Complex I biogenesis and links ECSIT phosphorylation to Alzheimer's disease pathology.