The structural mechanism of MCIA complex assembly links mitochondrial redox pathways
Lindsay McGregor, Samira Acajjaoui, Ambroise Desfosses, Melissa Saïdi, Maria Bacia‐Verloop, Jennifer Schwarz, Pauline Juyoux, Jill von Velsen, Matthew W. Bowler, Andrew A. McCarthy, Eaazhisai Kandiah, Gordon A. Leonard, Irina Gutsche, Montserrat Soler‐López
This study reveals the structural mechanism of MCIA complex assembly, showing how ECSIT and ACAD9 interact to facilitate Complex I biogenesis and links ECSIT phosphorylation to Alzheimer's disease pathology.
bioRxiv · Feb 23, 2023 · PreprintMolecular Biology