Matthew W. Bowler

The paper maps the fragment-binding landscape of SARS-CoV-2 nsp14, identifies promising sites for antiviral drug development, and provides a prioritized resource for future inhibitors.

EasyGrid automates cryo-EM sample preparation and quality control, improving vitrification for macromolecules and mammalian cells.

The paper determines cryo-EM structures of MEK1 activating ERK2, elucidating specificity and activation mechanisms in the MAPK pathway.

This study identifies two copper transporters in Toxoplasma gondii and shows their roles in parasite metabolism and persistence.

The paper identifies Hydra, a novel domain in TgSNF2L that drives multimerization and contributes to ISWI diversification in Toxoplasma gondii.

The paper shows that MAP2Ks can phosphorylate and activate MAPKs using ADP in vitro, suggesting a potential role in maintaining signaling under ATP-depleted conditions.

The paper describes metal fluorides as tools for studying phosphoryl transfer enzymes, highlighting their use in structural biology techniques and introducing scandium tetrafluoride as a new analog.

This paper introduces an in situ serial crystallography method for analyzing 96-well plates, enabling structure determination of challenging samples at low symmetry.

This study reveals the structural mechanism of MCIA complex assembly, showing how ECSIT and ACAD9 interact to facilitate Complex I biogenesis and links ECSIT phosphorylation to Alzheimer's disease pathology.

The paper describes improvements to the automatic characterization and data collection algorithms on the MASSIF-1 beamline, enhancing data quality and throughput.